清华大学基础医学院常智杰教授团队联合解放军总医院等单位，在国际顶尖期刊Signal Transduction and Targeted Therapy（Nature子刊）发表重磅研究成果，证实雾化吸入人脐带间充质干细胞外泌体（hUCMSC-EVs）可安全、有效逆转肺纤维化。
Designed for Pulmonary Nodules · Pulmonary Fibrosis · Lung Function Restoration
Stem Cell Exosome
Exosomes derived from umbilical cord mesenchymal stem cells, carrying 450+ active factors, delivered directly to the lungs via nebulization
CXCR4 receptors on exosome surface identify lung lesions, actively accumulating in damaged areas with no systemic toxicity.
Suppresses TNF-α, IL-6, IL-1β and other pro-inflammatory factors; induces macrophage M1→M2 polarization, breaking the chronic inflammation cycle.
Carries HGF, EGF, FGF, VEGF and 450+ growth factors, stimulating alveolar epithelial cell proliferation and repairing damaged alveolar structures.
Downregulates TGF-β expression, reduces excessive collagen deposition, halts "scarring" progression and reverses established fibrotic lesions.
PIC/S GMP certified + A/B grade sterile production. Animal-origin-free (AOF) culture medium ensures absolute safety and purity.
Inhaled via nebulizer in 10–15 minutes, painless and non-invasive, reaching deep lung tissue. Suitable for elderly patients; no injection required.
After nebulized inhalation, exosomes repair the lungs through four core mechanisms
Nano-scale exosomes (30–150 nm) are aerosolized by a nebulizer, penetrating deep into alveoli and targeting inflamed/fibrotic lesion zones.
Releases miRNA-21, miRNA-146a and other regulatory molecules, suppressing the NF-κB inflammatory pathway and resolving chronic lung inflammation at the source.
HGF, EGF, VEGF and 450+ growth factors act on damaged cells, activating Type II alveolar epithelial proliferation and rebuilding alveolar structures.
TGF-β signaling is potently inhibited, excessive collagen deposition is reduced, established fibrotic lesions gradually dissolve — visible regression on HRCT.
hUCMSC-EVs · Nano-scale Cell Vesicles
Diameter 30–150 nm
Real patient data from clinical reports, each case with before/after CT imaging comparison
Institutional Partners & Support
Tracking the latest research and clinical advances in stem cell exosome therapy
清华大学基础医学院常智杰教授团队联合解放军总医院等单位，在国际顶尖期刊Signal Transduction and Targeted Therapy（Nature子刊）发表重磅研究成果，证实雾化吸入人脐带间充质干细胞外泌体（hUCMSC-EVs）可安全、有效逆转肺纤维化。
42岁女性患者，左肺下叶外基底段孤立磨玻璃结节（直径约8mm），抗炎治疗3个月无效后，采用脐带间充质干细胞外泌体雾化治疗，17天后病灶完全吸收。
清华大学医学院常智杰课题组开发了利用脐带来源间充质干细胞的细胞外囊泡（外泌体）雾化吸入治疗肺纤维化的方法，并完成了全球首个该领域的I期临床试验。
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