Research News

Tsinghua Team Breakthrough: Inhaled Stem Cell Exosomes Reverse Pulmonary Fibrosis in 7 Days — 24-Patient Clinical Data Published in Nature Sub-journal

Tsinghua University Chang Zhijie Team Signal Transduction and Targeted Therapy (Nature Sub-journal) 2026年06月07日 32

A research team led by Professor Chang Zhijie from the School of Basic Medical Sciences, Tsinghua University, in collaboration with the PLA General Hospital and other institutions, has published landmark findings in the prestigious journal Signal Transduction and Targeted Therapy (a Nature sub-journal), demonstrating that inhaled human umbilical cord mesenchymal stem cell exosomes (hUCMSC-EVs) can safely and effectively reverse pulmonary fibrosis.

Research Background

Pulmonary fibrosis is known as "the cancer that is not cancer." Conventional drugs can only slow progression but cannot reverse scarring.

Key Data

Mean FVC improvement: +12.5%
83.3% of patients showed improvement in ≥3 indicators
2 patients showed significant lesion regression on HRCT
Zero serious adverse events throughout the study

Mechanism of Action

Works through three major mechanisms — anti-inflammation, tissue repair, and anti-fibrosis — directly targeting pulmonary lesions.

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